How useful are invertebrate infection models for studying bacterial Assignment

How useful are invertebrate contagious disease models for studying bacterial pathogenisis and therapy - Assignment ExampleThe infection cycle involves the disease causing agent managing entry into the host either through adhesion or penetration, assimilation of nutrients to generate more copies of itself and subvert the defence systems of the host and eventually exit from the host to work another cycle in a different target. Numerous in vitro and in vivo infection models yield been developed over the years to identify sharpness factors and understand its regulation. The fact that some of the host-pathogen interactions eat up been evolutionarily maintain has led to the establishment of model systems to understand pathogenesis from both the hosts and pathogens side. Much remains to be understood rough the host-pathogen interaction at the molecular level and model systems that are most informative of this could be systems in which the pathogen and host are both amenable to geneti c analysis (Pradel and Ewbank, 2004).A number of non-vertebrate model organisms have been developed in order to study host-pathogen interactions which facilitates not only a better understanding of virulence mechanisms but in addition permit direct genetic techniques to study host defences while reducing invent up and ethical constraints associated with mammalian model systems. Non-vertebrate models have also been more popular in bacterial pathogenesis studies because of the by-line factorsTo understand the complexity of virulence-defence interactions a number of pathogen-host systems are required. Simple easy to handle organism such as D. discoideum, C. elegans, D. melanogaster and G. mellonella helps in identifying virulence factors and understanding their functions. Comparative studies in host models also contribute to the denomination of novel elements involved in host susceptibility and resistance. Some of these elements conserved over species may also contribute to our u nderstanding of pathogenesis in vertebrates. The genetic tractability of the simple host models will also make possible refined